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Title:

Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hammelmann, Verena; Stieglitz, Marc Sebastian; Hülle, Henrik; Le Meur, Karim; Kass, Jennifer; Brümmer, Manuela; Gruner, Christian; Rötzer, René Dominik; Fenske, Stefanie; Hartmann, Jana; Zott, Benedikt; Lüthi, Anita; Spahn, Saskia; Moser, Markus; Isbrandt, Dirk; Ludwig, Andreas; Konnerth, Arthur; Wahl-Schott, Christian; Biel, Martin
Abstract:
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are dually gated channels that are operated by voltage and by neurotransmitters via the cAMP system. cAMP-dependent HCN regulation has been proposed to play a key role in regulating circuit behavior in the thalamus. By analyzing a knockin mouse model (HCN2EA), in which binding of cAMP to HCN2 was abolished by 2 amino acid exchanges (R591E, T592A), we found that cAMP gating of HCN2 is essential for regulating the transition betwee...     »
Journal title abbreviation:
JCI Insight
Year:
2019
Journal volume:
4
Journal issue:
9
Fulltext / DOI:
doi:10.1172/jci.insight.126418
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31045576
Print-ISSN:
2379-3708
TUM Institution:
Institut für Neurowissenschaften
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