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Title:

TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
O'Neill, Thomas J; Seeholzer, Thomas; Gewies, Andreas; Gehring, Torben; Giesert, Florian; Hamp, Isabel; Graß, Carina; Schmidt, Henrik; Kriegsmann, Katharina; Tofaute, Marie J; Demski, Katrin; Poth, Tanja; Rosenbaum, Marc; Schnalzger, Theresa; Ruland, Jürgen; Göttlicher, Martin; Kriegsmann, Mark; Naumann, Ronald; Heissmeyer, Vigo; Plettenburg, Oliver; Wurst, Wolfgang; Krappmann, Daniel
Abstract:
Balanced control of T cell signaling is critical for adaptive immunity and protection from autoimmunity. By combining genetically engineered mouse models, biochemical analyses and pharmacological interventions, we describe an unexpected dual role of the tumor necrosis factor receptor–associated factor 6 (TRAF6) E3 ligase as both a positive and negative regulator of mucosa-associated lymphoid tissue 1 (MALT1) paracaspase. Although MALT1-TRAF6 recruitment is indispensable for nuclear factor κB sig...     »
Journal title abbreviation:
Sci Immunol
Year:
2021
Journal volume:
6
Journal issue:
65
Fulltext / DOI:
doi:10.1126/sciimmunol.abh2095
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34767456
Print-ISSN:
2470-9468
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Institut für Toxikologie und Umwelthygiene
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