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Titel:

Morphomolecular analysis of the immune tumor microenvironment in human head and neck cancer.

Dokumenttyp:
Journal Article
Autor(en):
Badr, Mohamed; Jöhrens, Korinna; Allgäuer, Michael; Boxberg, Melanie; Weichert, Wilko; Tinhofer, Ingeborg; Denkert, Carsten; Schirmacher, Peter; Stenzinger, Albrecht; Budczies, Jan
Abstract:
Immunotherapy is effective in head and neck squamous cell carcinoma (HNSCC), but only a minority of patients responds to immune checkpoint blockade (ICB). To contribute to a better understanding of the underlying immune biology, we combined histomorphological evaluation and molecular analysis of the HNSCC immune microenvironment in the TCGA cohort. Analyzing digital HE-stained slides, a method for classification of tumor infiltrating lymphocytes (TILs) in the intra-epithelial compartment (ieTILs...     »
Zeitschriftentitel:
Cancer Immunol Immunother
Jahr:
2019
Band / Volume:
68
Heft / Issue:
9
Seitenangaben Beitrag:
1443-1454
Volltext / DOI:
doi:10.1007/s00262-019-02378-w
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31444607
Print-ISSN:
0340-7004
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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