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Title:

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

Document type:
Review; Book Chapter; Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Zott, Benedikt; Busche, Marc Aurel; Sperling, Reisa A; Konnerth, Arthur
Abstract:
A major mystery of many types of neurological and psychiatric disorders, such as Alzheimer's disease (AD), remains the underlying, disease-specific neuronal damage. Because of the strong interconnectivity of neurons in the brain, neuronal dysfunction necessarily disrupts neuronal circuits. In this article, we review evidence for the disruption of large-scale networks from imaging studies of humans and relate it to studies of cellular dysfunction in mouse models of AD. The emerging picture is tha...     »
Journal title abbreviation:
Annu Rev Neurosci
Year:
2018
Journal volume:
41
Pages contribution:
277-297
Fulltext / DOI:
doi:10.1146/annurev-neuro-080317-061725
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29986165
Print-ISSN:
0147-006X
TUM Institution:
Institut für Neurowissenschaften
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