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Titel:

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

Dokumenttyp:
Review; Book Chapter; Journal Article; Research Support, Non-U.S. Gov't; Review
Autor(en):
Zott, Benedikt; Busche, Marc Aurel; Sperling, Reisa A; Konnerth, Arthur
Abstract:
A major mystery of many types of neurological and psychiatric disorders, such as Alzheimer's disease (AD), remains the underlying, disease-specific neuronal damage. Because of the strong interconnectivity of neurons in the brain, neuronal dysfunction necessarily disrupts neuronal circuits. In this article, we review evidence for the disruption of large-scale networks from imaging studies of humans and relate it to studies of cellular dysfunction in mouse models of AD. The emerging picture is tha...     »
Zeitschriftentitel:
Annu Rev Neurosci
Jahr:
2018
Band / Volume:
41
Seitenangaben Beitrag:
277-297
Volltext / DOI:
doi:10.1146/annurev-neuro-080317-061725
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29986165
Print-ISSN:
0147-006X
TUM Einrichtung:
Institut für Neurowissenschaften
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