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Title:

Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Brandl, Lydia; Zhang, Yina; Kirstein, Nina; Sendelhofert, Andrea; Boos, Sophie Luise; Jung, Peter; Greten, Florian; Rad, Roland; Menssen, Antje
Abstract:
We recently described a positive feedback loop connecting c-MYC, NAMPT, DBC1 and SIRT1 that contributes to unrestricted cancer cell proliferation. Here we determine the relevance of the loop for serrated route intestinal tumorigenesis using genetically well-defined BrafV600E and K-rasG12D mouse models. In both models we show that c-MYC and SIRT1 protein expression increased through progression from hyperplasia to invasive carcinomas and metastases. It correlated with high NAMPT expression and wa...     »
Journal title abbreviation:
Neoplasia
Year:
2019
Journal volume:
21
Journal issue:
10
Pages contribution:
974-988
Fulltext / DOI:
doi:10.1016/j.neo.2019.07.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31442917
Print-ISSN:
1522-8002
TUM Institution:
Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
 BibTeX