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Title:

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.

Document type:
Article; Journal Article
Author(s):
Garg, Garima; Muschaweckh, Andreas; Moreno, Helena; Vasanthakumar, Ajithkumar; Floess, Stefan; Lepennetier, Gildas; Oellinger, Rupert; Zhan, Yifan; Regen, Tommy; Hiltensperger, Michael; Peter, Christian; Aly, Lilian; Knier, Benjamin; Palam, Lakshmi Reddy; Kapur, Reuben; Kaplan, Mark H; Waisman, Ari; Rad, Roland; Schotta, Gunnar; Huehn, Jochen; Kallies, Axel; Korn, Thomas
Abstract:
Foxp3+ regulatory T (Treg) cells restrict immune pathology in inflamed tissues; however, an inflammatory environment presents a threat to Treg cell identity and function. Here, we establish a transcriptional signature of central nervous system (CNS) Treg cells that accumulate during experimental autoimmune encephalitis (EAE) and identify a pathway that maintains Treg cell function and identity during severe inflammation. This pathway is dependent on the transcriptional regulator Blimp1, which p...     »
Journal title abbreviation:
Cell Rep
Year:
2019
Journal volume:
26
Journal issue:
7
Pages contribution:
1854-1868.e5
Fulltext / DOI:
doi:10.1016/j.celrep.2019.01.070
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30759395
Print-ISSN:
2211-1247
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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