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Title:

A vicious cycle of β amyloid-dependent neuronal hyperactivation.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Zott, Benedikt; Simon, Manuel M; Hong, Wei; Unger, Felix; Chen-Engerer, Hsing-Jung; Frosch, Matthew P; Sakmann, Bert; Walsh, Dominic M; Konnerth, Arthur
Abstract:
β-amyloid (Aβ)-dependent neuronal hyperactivity is believed to contribute to the circuit dysfunction that characterizes the early stages of Alzheimer's disease (AD). Although experimental evidence in support of this hypothesis continues to accrue, the underlying pathological mechanisms are not well understood. In this experiment, we used mouse models of Aβ-amyloidosis to show that hyperactivation is initiated by the suppression of glutamate reuptake. Hyperactivity occurred in neurons with preexi...     »
Journal title abbreviation:
Science
Year:
2019
Journal volume:
365
Journal issue:
6453
Pages contribution:
559-565
Fulltext / DOI:
doi:10.1126/science.aay0198
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31395777
Print-ISSN:
0036-8075
TUM Institution:
Institut für Neurowissenschaften
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