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Title:

Two types of functionally distinct Ca2+ stores in hippocampal neurons.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Chen-Engerer, Hsing-Jung; Hartmann, Jana; Karl, Rosa Maria; Yang, Jun; Feske, Stefan; Konnerth, Arthur
Abstract:
It is widely assumed that inositol trisphosphate (IP3) and ryanodine (Ry) receptors share the same Ca2+ pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP3- and Ry-receptors are associated with two functionally distinct intracellular Ca2+ stores, respectively. While the IP3-sensitive Ca2+ store refilling requires Orai2 channels, Ry-sensitive Ca2+ store refilling involves voltage-gated Ca2+ channels (VGCCs). Our findings have direct implications for...     »
Journal title abbreviation:
Nat Commun
Year:
2019
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-019-11207-8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31324793
Print-ISSN:
2041-1723
TUM Institution:
Institut für Neurowissenschaften
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