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Titel:

A vicious cycle of β amyloid-dependent neuronal hyperactivation.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Zott, Benedikt; Simon, Manuel M; Hong, Wei; Unger, Felix; Chen-Engerer, Hsing-Jung; Frosch, Matthew P; Sakmann, Bert; Walsh, Dominic M; Konnerth, Arthur
Abstract:
β-amyloid (Aβ)-dependent neuronal hyperactivity is believed to contribute to the circuit dysfunction that characterizes the early stages of Alzheimer's disease (AD). Although experimental evidence in support of this hypothesis continues to accrue, the underlying pathological mechanisms are not well understood. In this experiment, we used mouse models of Aβ-amyloidosis to show that hyperactivation is initiated by the suppression of glutamate reuptake. Hyperactivity occurred in neurons with preexi...     »
Zeitschriftentitel:
Science
Jahr:
2019
Band / Volume:
365
Heft / Issue:
6453
Seitenangaben Beitrag:
559-565
Volltext / DOI:
doi:10.1126/science.aay0198
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31395777
Print-ISSN:
0036-8075
TUM Einrichtung:
Institut für Neurowissenschaften
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