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Title:

The Helicobacter pylori HopQ outermembrane protein inhibits immune cell activities.

Document type:
Journal Article
Author(s):
Gur, Chamutal; Maalouf, Naseem; Gerhard, Markus; Singer, Bernhard B; Emgård, Johanna; Temper, Violeta; Neuman, Tzahi; Mandelboim, Ofer; Bachrach, Gilad
Abstract:
We previously showed that the colorectal cancer colonizing bacterium Fusobacterium nucleatum protects tumors from immune cell attack via binding of the fusbacterial Fap2 outer-membrane protein to TIGIT, a checkpoint inhibitory receptor expressed on T cells and NK cells. Helicobacter pylori, the causative agent for peptic ulcer disease, is associated with the development of gastric adenocarcinoma and MALT lymphoma. The HopQ outer-membrane adhesin of H. pylori was recently shown to bind carcinoemb...     »
Journal title abbreviation:
Oncoimmunology
Year:
2019
Journal volume:
8
Journal issue:
4
Fulltext / DOI:
doi:10.1080/2162402X.2018.1553487
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30906650
Print-ISSN:
2162-4011
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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