Disentangling -cooperating tumor suppressor gene networks in cancer.
Document type:
Journal Article; 4
Author(s):
de la Rosa, Jorge; Weber, Julia; Rad, Roland; Bradley, Allan; Cadiñanos, Juan
Abstract:
We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the functional and clinical relevance of several promising candidates for human prostate cancer.