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Title:

Surface loops of trypsin-like serine proteases as determinants of function.

Document type:
Review; Journal Article; Review
Author(s):
Goettig, Peter; Brandstetter, Hans; Magdolen, Viktor
Abstract:
Trypsin and chymotrypsin-like serine proteases from family S1 (clan PA) constitute the largest protease group in humans and more generally in vertebrates. The prototypes chymotrypsin, trypsin and elastase represent simple digestive proteases in the gut, where they cleave nearly any protein. Multidomain trypsin-like proteases are key players in the tightly controlled blood coagulation and complement systems, as well as related proteases that are secreted from diverse immune cells. Some serine pro...     »
Journal title abbreviation:
Biochimie
Year:
2019
Journal volume:
166
Pages contribution:
52-76
Fulltext / DOI:
doi:10.1016/j.biochi.2019.09.004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31505212
Print-ISSN:
0300-9084
TUM Institution:
Frauenklinik und Poliklinik
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