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- Titel:
Properties of myenteric neurones and mucosal functions in the distal colon of diet-induced obese mice.
- Dokumenttyp:
- Zeitschriftenaufsatz
- Autor(en):
- Reichardt, Francois; Baudry, Charlotte; Gruber, Lisa; Mazzuoli, Gemma; Moriez, Raphael; Scherling, Christian; Kollmann, Patrick; Daniel, Hannelore; Kisling, Sigrid; Haller, Dirk; Neunlist, Michel; Schemann, Michael
- Abstract:
- Colonic transit and mucosal integrity are believed to be impaired in obesity. However, a comprehensive assessment of altered colonic functions, inflammatory changes and neuronal signalling of obese animals is missing. In mice, we studied the impact of diet-induced obesity (DIO) on: (i) in vivo colonic transit; (ii) signalling in the myenteric plexus by recording responses to nicotine and
- Stichworte:
- Membrane Potentials, Mice, Inbred C57BL, Animals, Mice, Male, Nicotine/pharmacology, Adipose Tissue/metabolism, Colon/cytology/innervation/*metabolism/physiopathology, Cytokines/genetics/metabolism, Dietary Carbohydrates/adverse effects, Homeodomain Proteins/genetics/metabolism, Intestinal Mucosa/*metabolism/physiopathology, Myenteric Plexus/cytology/*metabolism/physiopathology, Neurons/drug effects/*metabolism/physiology, Obesity/chemically induced/*metabolism/physiopathology, Paired Box Transcription Factors/genetics/metabolism, Permeability, Serotonin Plasma Membrane Transport Proteins/genetics/metabolism, Serotonin/analogs & derivatives/pharmacology, Tryptophan Hydroxylase/genetics/metabolism
- Zeitschriftentitel:
- The Journal of physiology
- Jahr:
- 2013
- Band / Volume:
- 591
- Monat:
- oct
- Heft / Issue:
- 20
- Seitenangaben Beitrag:
- 5125--5139
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1113/jphysiol.2013.262733
- Print-ISSN:
- 1469-7793 0022-3751
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