Benutzer: Gast  Login
Titel:

Activation and modulation of recombinantly expressed serotonin receptor type 3A by terpenes and pungent substances

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Ziemba, Paul M.; Schreiner, Benjamin S. P.; Flegel, Caroline; Herbrechter, Robin; Stark, Timo D.; Hofmann, Thomas; Hatt, Hanns; Werner, Markus; Gisselmann, Gunter
Abstract:
Serotonin receptor type 3 (5-HT3 receptor) is a ligand-gated ion channel that is expressed in the central nervous system (CNS) as well as in the peripheral nervous system (PNS). The receptor plays an important role in regulating peristalsis of the gastrointestinal tract and in functions such as emesis, cognition and anxiety. Therefore, a variety of pharmacologically active substances target the 5-HT3 receptor to treat chemotherapy-induced nausea and vomiting. The 5-HT3 receptors are activated, a...     »
Zeitschriftentitel:
Biochemical and biophysical research communications
Jahr:
2015
Band / Volume:
467
Heft / Issue:
4
Seitenangaben Beitrag:
1090--1096
Volltext / DOI:
doi:10.1016/j.bbrc.2015.09.074
Print-ISSN:
0006-291X
 BibTeX