Benutzer: Gast  Login
Titel:

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.

Dokumenttyp:
Article; Journal Article
Autor(en):
O'Connor, Tracy; Zhou, Xiaolan; Kosla, Jan; Adili, Arlind; Garcia Beccaria, Maria; Kotsiliti, Elena; Pfister, Dominik; Johlke, Anna-Lena; Sinha, Ankit; Sankowski, Roman; Schick, Markus; Lewis, Richard; Dokalis, Nikolaos; Seubert, Bastian; Höchst, Bastian; Inverso, Donato; Heide, Danijela; Zhang, Wenlong; Weihrich, Petra; Manske, Katrin; Wohlleber, Dirk; Anton, Martina; Hoellein, Alexander; Seleznik, Gitta; Bremer, Juliane; Bleul, Sabine; Augustin, Hellmut G; Scherer, Florian; Koedel, Uwe; Weber,...     »
Abstract:
How lymphoma cells (LCs) invade the brain during the development of central nervous system lymphoma (CNSL) is unclear. We found that NF-κB-induced gliosis promotes CNSL in immunocompetent mice. Gliosis elevated cell-adhesion molecules, which increased LCs in the brain but was insufficient to induce CNSL. Astrocyte-derived CCL19 was required for gliosis-induced CNSL. Deleting CCL19 in mice or CCR7 from LCs abrogated CNSL development. Two-photon microscopy revealed LCs transiently entering normal...     »
Zeitschriftentitel:
Cancer Cell
Jahr:
2019
Band / Volume:
36
Heft / Issue:
3
Seitenangaben Beitrag:
250-267.e9
Volltext / DOI:
doi:10.1016/j.ccell.2019.08.001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31526758
Print-ISSN:
1535-6108
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Experimentelle Onkologie und Therapieforschung; Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
 BibTeX