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Titel:

Defective cholesterol clearance limits remyelination in the aged central nervous system.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Cantuti-Castelvetri, Ludovico; Fitzner, Dirk; Bosch-Queralt, Mar; Weil, Marie-Theres; Su, Minhui; Sen, Paromita; Ruhwedel, Torben; Mitkovski, Miso; Trendelenburg, George; Lütjohann, Dieter; Möbius, Wiebke; Simons, Mikael
Abstract:
Age-associated decline in regeneration capacity limits the restoration of nervous system functionality after injury. In a model for demyelination, we found that old mice fail to resolve the inflammatory response initiated after myelin damage. Aged phagocytes accumulated excessive amounts of myelin debris, which triggered cholesterol crystal formation and phagolysosomal membrane rupture and stimulated inflammasomes. Myelin debris clearance required cholesterol transporters, including apolipoprote...     »
Zeitschriftentitel:
Science
Jahr:
2018
Band / Volume:
359
Heft / Issue:
6376
Seitenangaben Beitrag:
684-688
Volltext / DOI:
doi:10.1126/science.aan4183
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29301957
Print-ISSN:
0036-8075
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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