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Titel:

HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Göder, Anja; Emmerich, Claudia; Nikolova, Teodora; Kiweler, Nicole; Schreiber, Maria; Kühl, Toni; Imhof, Diana; Christmann, Markus; Heinzel, Thorsten; Schneider, Günter; Krämer, Oliver H
Abstract:
Checkpoint kinases sense replicative stress to prevent DNA damage. Here we show that the histone deacetylases HDAC1/HDAC2 sustain the phosphorylation of the checkpoint kinases ATM, CHK1 and CHK2, activity of the cell cycle gatekeeper kinases WEE1 and CDK1, and induction of the tumour suppressor p53 in response to stalled DNA replication. Consequently, HDAC inhibition upon replicative stress promotes mitotic catastrophe. Mechanistically, HDAC1 and HDAC2 suppress the expression of PPP2R3A/PR130, a...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2018
Band / Volume:
9
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-018-03096-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29472538
Print-ISSN:
2041-1723
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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