Phenomenology of bubble-collapse-driven penetration of biomaterial-surrogate liquid-liquid interfaces

The paper presents phenomenology of interaction and penetration of liquid-liquid material interfaces initiated by shock-driven collapse of single and multiple microbubbles situated near the material interface. Previous experimental studies have established such a generic setting as relevant for the investigation of sonoporation, i.e., the perforation of live cells by microbubble collapses. We consider a planar or spherical, single- or dual-layer, material interface between a gelatin material and water. A single or several ideal-gas microbubbles are positioned near the interface. Bubble collapse is initiated by a shock wave with a pressure profile specific to laser generation and is flat when hitting the gas-water interface. The interfacial acoustic impedance match singles out the collapse-induced re-entrant jet as main event. High-resolution sharp-interface numerical methods are employed to ensure that wave dynamics, hydrodynamics, and interface transporting are accurately resolved. Bubble configurations are varied between single and double and between attached and with standoff distance. Parameters varied are shock-wave peak pressure and viscosity ratio between single and double layers of gelatin and the surrounding water. For inertia-dominated cases, two regimes are observed, the first characterized by linear growth of the penetration depth and the second by a t(2/3) scaling. The latter range is affected by viscosity which reduces penetration speed. The results show that process parameters, in particular shock overpressure, control not only penetration depth but also the size of the interface perforation, indicating means to steer processes in biomedical applications.     «

The paper presents phenomenology of interaction and penetration of liquid-liquid material interfaces initiated by shock-driven collapse of single and multiple microbubbles situated near the material interface. Previous experimental studies have established such a generic setting as relevant for the investigation of sonoporation, i.e., the perforation of live cells by microbubble collapses. We consider a planar or spherical, single- or dual-layer, material interface between a gelatin material and...     »