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Title:

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Snaidero, Nicolas; Velte, Caroline; Myllykoski, Matti; Raasakka, Arne; Ignatev, Alexander; Werner, Hauke B; Erwig, Michelle S; Möbius, Wiebke; Kursula, Petri; Nave, Klaus-Armin; Simons, Mikael
Abstract:
The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent studies indicate that myelin is metabolically active and capable of communicating with the underlying axon. To be functionally connected to the neuron, oligodendrocytes maintain non-compacted myelin as cytoplasmic nanochannels. Here, we used high-pressure freezing for electron microscopy to study these cytoplasmic regions within myelin close...     »
Journal title abbreviation:
Cell Rep
Year:
2017
Journal volume:
18
Journal issue:
2
Pages contribution:
314-323
Language:
eng
Fulltext / DOI:
doi:10.1016/j.celrep.2016.12.053
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28076777
Print-ISSN:
2211-1247
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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