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Title:

Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture.

Document type:
Journal Article; Review; Review
Author(s):
Misgeld, Thomas; Schwarz, Thomas L
Abstract:
Neurons have more extended and complex shapes than other cells and consequently face a greater challenge in distributing and maintaining mitochondria throughout their arbors. Neurons can last a lifetime, but proteins turn over rapidly. Mitochondria, therefore, need constant rejuvenation no matter how far they are from the soma. Axonal transport of mitochondria and mitochondrial fission and fusion contribute to this rejuvenation, but local protein synthesis is also likely. Maintenance of a health...     »
Journal title abbreviation:
Neuron
Year:
2017
Journal volume:
96
Journal issue:
3
Pages contribution:
651-666
Language:
eng
Fulltext / DOI:
doi:10.1016/j.neuron.2017.09.055
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29096078
Print-ISSN:
0896-6273
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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