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Title:

Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Lüders, Katja A; Patzig, Julia; Simons, Mikael; Nave, Klaus-Armin; Werner, Hauke B
Abstract:
Proteolipid protein (PLP) is the most abundant integral membrane protein in compact central nervous system myelin, and null mutations of the PLP1 gene cause spastic paraplegia type 2 (SPG2). SPG2 patients and PLP-deficient mice exhibit only moderate abnormalities of myelin but progressive degeneration of long axons. Since Plp1 gene products are detected in a subset of neurons it has been suggested that the loss of neuronal Plp1 expression could be the cause of the axonal pathology. To test this...     »
Journal title abbreviation:
Glia
Year:
2017
Journal volume:
65
Journal issue:
11
Pages contribution:
1762-1776
Language:
eng
Fulltext / DOI:
doi:10.1002/glia.23193
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28836307
Print-ISSN:
0894-1491
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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