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Titel:

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions.

Dokumenttyp:
Journal Article; Article
Autor(en):
Fard, Maryam K; van der Meer, Franziska; Sánchez, Paula; Cantuti-Castelvetri, Ludovico; Mandad, Sunit; Jäkel, Sarah; Fornasiero, Eugenio F; Schmitt, Sebastian; Ehrlich, Marc; Starost, Laura; Kuhlmann, Tanja; Sergiou, Christina; Schultz, Verena; Wrzos, Claudia; Brück, Wolfgang; Urlaub, Henning; Dimou, Leda; Stadelmann, Christine; Simons, Mikael
Abstract:
Investigations into brain function and disease depend on the precise classification of neural cell types. Cells of the oligodendrocyte lineage differ greatly in their morphology, but accurate identification has thus far only been possible for oligodendrocyte progenitor cells and mature oligodendrocytes in humans. We find that breast carcinoma amplified sequence 1 (BCAS1) expression identifies an oligodendroglial subpopulation in the mouse and human brain. These cells are newly formed, myelinatin...     »
Zeitschriftentitel:
Sci Transl Med
Jahr:
2017
Band / Volume:
9
Heft / Issue:
419
Sprache:
eng
Volltext / DOI:
doi:10.1126/scitranslmed.aam7816
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29212715
Print-ISSN:
1946-6234
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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