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Title:

Non-invasive imaging of engineered human tumors in the living chicken embryo.

Document type:
journal article
Author(s):
Jefferies, Benedict; Lenze, Florian; Sathe, Anuja; Truong, Nguyen; Anton, Martina; von Eisenhart-Rothe, Rüdiger; Nawroth, Roman; Mayer-Kuckuk, Philipp
Abstract:
The growing interest in engineered tumor models prompted us to devise a method for the non-invasive assessment of such models. Here, we report on bioluminescence imaging (BLI) for the assessment of engineered tumor models in the fertilized chicken egg, i.e, chick chorioallantoic membrane (CAM) assay. One prostate cancer (PC-3) and two osteosarcoma (MG63 and HOS) cell lines were modified with luciferase reporter genes. To create engineered tumors, these cell lines were seeded either onto basement...     »
Journal title abbreviation:
Sci Rep
Year:
2017
Journal volume:
7
Journal issue:
1
Pages contribution:
4991
Language:
eng
Fulltext / DOI:
doi:10.1038/s41598-017-04572-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28694510
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung
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