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Title:

cmRNA/lipoplex encapsulation in PLGA microspheres enables transfection via calcium phosphate cement (CPC)/PLGA composites.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Utzinger, Maximilian; Jarzebinska, Anita; Haag, Nicolas; Schweizer, Martin; Winter, Gerhard; Dohmen, Christian; Rudolph, Carsten; Plank, Christian
Abstract:
In this study lipoplexes containing chemically modified messenger RNA (cmRNA) were incorporated into poly (lactic-co-glycolic acid) (PLGA) microspheres via water-in-oil-in-water (W/O/W) double emulsion solvent evaporation technique. The nanoparticle encapsulation by microparticle formation was optimized to achieve lipoplex release and maximum transfection efficiency in surrounding cells. It was possible to adjust characteristic features in surface topology and size of the PLGA-microspheres by va...     »
Journal title abbreviation:
J Control Release
Year:
2017
Journal volume:
249
Pages contribution:
143-149
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jconrel.2017.01.045
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28161466
Print-ISSN:
0168-3659
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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