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Title:

Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.

Document type:
Journal Article
Author(s):
Sassi, Yassine; Avramopoulos, Petros; Ramanujam, Deepak; Grüter, Laurenz; Werfel, Stanislas; Giosele, Simon; Brunner, Andreas-David; Esfandyari, Dena; Papadopoulou, Aikaterini S; De Strooper, Bart; Hübner, Norbert; Kumarswamy, Regalla; Thum, Thomas; Yin, Xiaoke; Mayr, Manuel; Laggerbauer, Bernhard; Engelhardt, Stefan
Abstract:
Chronic cardiac stress induces pathologic hypertrophy and fibrosis of the myocardium. The microRNA-29 (miR-29) family has been found to prevent excess collagen expression in various organs, particularly through its function in fibroblasts. Here, we show that miR-29 promotes pathologic hypertrophy of cardiac myocytes and overall cardiac dysfunction. In a mouse model of cardiac pressure overload, global genetic deletion of miR-29 or antimiR-29 infusion prevents cardiac hypertrophy and fibrosis and...     »
Journal title abbreviation:
Nat Commun
Year:
2017
Journal volume:
8
Journal issue:
1
Pages contribution:
1614
Language:
eng
Fulltext / DOI:
doi:10.1038/s41467-017-01737-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29158499
Print-ISSN:
2041-1723
TUM Institution:
Institut für Pharmakologie und Toxikologie
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