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Title:

Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Nystoriak, Matthew A; Nieves-Cintrón, Madeline; Patriarchi, Tommaso; Buonarati, Olivia R; Prada, Maria Paz; Morotti, Stefano; Grandi, Eleonora; Fernandes, Julia Dos Santos; Forbush, Katherine; Hofmann, Franz; Sasse, Kent C; Scott, John D; Ward, Sean M; Hell, Johannes W; Navedo, Manuel F
Abstract:
Hypercontractility of arterial myocytes and enhanced vascular tone during diabetes are, in part, attributed to the effects of increased glucose (hyperglycemia) on L-type Ca1.2 channels. In murine arterial myocytes, kinase-dependent mechanisms mediate the increase in Ca1.2 activity in response to increased extracellular glucose. We identified a subpopulation of the Ca1.2 channel pore-forming subunit (?1) within nanometer proximity of protein kinase A (PKA) at the sarcolemma of murine and human ar...     »
Journal title abbreviation:
Sci Signal
Year:
2017
Journal volume:
10
Journal issue:
463
Language:
eng
Fulltext / DOI:
doi:10.1126/scisignal.aaf9647
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28119464
Print-ISSN:
1945-0877
TUM Institution:
Institut für Pharmakologie und Toxikologie
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