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Title:

Preferential microRNA targeting revealed by in vivo competitive binding and differential Argonaute immunoprecipitation.

Document type:
Comparative Study; Journal Article
Author(s):
Werfel, Stanislas; Leierseder, Simon; Ruprecht, Benjamin; Kuster, Bernhard; Engelhardt, Stefan
Abstract:
MicroRNAs (miRNAs) have been described to simultaneously inhibit hundreds of targets, albeit to a modest extent. It was recently proposed that there could exist more specific, exceptionally strong binding to a subgroup of targets. However, it is unknown, whether this is the case and how such targets can be identified. Using Argonaute2-ribonucleoprotein immunoprecipitation and in vivo competitive binding assays, we demonstrate for miRNAs-21, -199-3p and let-7 exceptional regulation of a subset of...     »
Journal title abbreviation:
Nucleic Acids Res
Year:
2017
Journal volume:
45
Journal issue:
17
Pages contribution:
10218-10228
Language:
eng
Fulltext / DOI:
doi:10.1093/nar/gkx640
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28973447
Print-ISSN:
0305-1048
TUM Institution:
Institut für Pharmakologie und Toxikologie
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