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Titel:

Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload.

Dokumenttyp:
Journal Article
Autor(en):
Toischer, Karl; Zhu, Wuqiang; Hünlich, Mark; Mohamed, Belal A; Khadjeh, Sara; Reuter, Sean P; Schäfer, Katrin; Ramanujam, Deepak; Engelhardt, Stefan; Field, Loren J; Hasenfuss, Gerd
Abstract:
Induction of the cell cycle is emerging as an intervention to treat heart failure. Here, we tested the hypothesis that enhanced cardiomyocyte renewal in transgenic mice expressing cyclin D2 would be beneficial during hemodynamic overload. We induced pressure overload by transthoracic aortic constriction (TAC) or volume overload by aortocaval shunt in cyclin D2-expressing and WT mice. Although cyclin D2 expression dramatically improved survival following TAC, it did not confer a survival advantag...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2017
Band / Volume:
127
Heft / Issue:
12
Seitenangaben Beitrag:
4285-4296
Sprache:
eng
Volltext / DOI:
doi:10.1172/JCI81870
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29083322
Print-ISSN:
0021-9738
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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