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Titel:

Preferential microRNA targeting revealed by in vivo competitive binding and differential Argonaute immunoprecipitation.

Dokumenttyp:
Comparative Study; Journal Article
Autor(en):
Werfel, Stanislas; Leierseder, Simon; Ruprecht, Benjamin; Kuster, Bernhard; Engelhardt, Stefan
Abstract:
MicroRNAs (miRNAs) have been described to simultaneously inhibit hundreds of targets, albeit to a modest extent. It was recently proposed that there could exist more specific, exceptionally strong binding to a subgroup of targets. However, it is unknown, whether this is the case and how such targets can be identified. Using Argonaute2-ribonucleoprotein immunoprecipitation and in vivo competitive binding assays, we demonstrate for miRNAs-21, -199-3p and let-7 exceptional regulation of a subset of...     »
Zeitschriftentitel:
Nucleic Acids Res
Jahr:
2017
Band / Volume:
45
Heft / Issue:
17
Seitenangaben Beitrag:
10218-10228
Sprache:
eng
Volltext / DOI:
doi:10.1093/nar/gkx640
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28973447
Print-ISSN:
0305-1048
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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