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Title:

Two serines in the distal C-terminus of the human ß1-adrenoceptor determine ß-arrestin2 recruitment.

Document type:
Journal Article
Author(s):
Hinz, Laura; Ahles, Andrea; Ruprecht, Benjamin; Kuster, Bernhard; Engelhardt, Stefan
Abstract:
G protein-coupled receptors (GPCRs) undergo phosphorylation at several intracellular residues by G protein-coupled receptor kinases. The resulting phosphorylation pattern triggers arrestin recruitment and receptor desensitization. The exact sites of phosphorylation and their function remained largely unknown for the human ?1-adrenoceptor (ADRB1), a key GPCR in adrenergic signal transduction and the target of widely used drugs such as ?-blockers. The present study aimed to identify the intracellu...     »
Journal title abbreviation:
PLoS ONE
Year:
2017
Journal volume:
12
Journal issue:
5
Pages contribution:
e0176450
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0176450
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28472170
Print-ISSN:
1932-6203
TUM Institution:
Institut für Pharmakologie und Toxikologie
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