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Titel:

BACE inhibition-dependent repair of Alzheimer's pathophysiology.

Dokumenttyp:
Journal Article; Article
Autor(en):
Keskin, Aylin D; Keku?, Maja; Adelsberger, Helmuth; Neumann, Ulf; Shimshek, Derya R; Song, Beomjong; Zott, Benedikt; Peng, Tingying; Förstl, Hans; Staufenbiel, Matthias; Nelken, Israel; Sakmann, Bert; Konnerth, Arthur; Busche, Marc Aurel
Abstract:
Amyloid-? (A?) is thought to play an essential pathogenic role in Alzheimer´s disease (AD). A key enzyme involved in the generation of A? is the ?-secretase BACE, for which powerful inhibitors have been developed and are currently in use in human clinical trials. However, although BACE inhibition can reduce cerebral A? levels, whether it also can ameliorate neural circuit and memory impairments remains unclear. Using histochemistry, in vivo Ca2+ imaging, and behavioral analyses in a mouse model...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2017
Band / Volume:
114
Heft / Issue:
32
Seitenangaben Beitrag:
8631-8636
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.1708106114
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28739891
Print-ISSN:
0027-8424
TUM Einrichtung:
Institut für Neurowissenschaften; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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