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Titel:

Tweety-Homolog 1 Drives Brain Colonization of Gliomas.

Dokumenttyp:
Journal Article
Autor(en):
Jung, Erik; Osswald, Matthias; Blaes, Jonas; Wiestler, Benedikt; Sahm, Felix; Schmenger, Torsten; Solecki, Gergely; Deumelandt, Katrin; Kurz, Felix T; Xie, Ruifan; Weil, Sophie; Heil, Oliver; Thomé, Carina; Gömmel, Miriam; Syed, Mustafa; Häring, Peter; Huber, Peter E; Heiland, Sabine; Platten, Michael; von Deimling, Andreas; Wick, Wolfgang; Winkler, Frank
Abstract:
Early and progressive colonization of the healthy brain is one hallmark of diffuse gliomas, including glioblastomas. We recently discovered ultralong (>10 to hundreds of microns) membrane protrusions [tumor microtubes (TMs)] extended by glioma cells. TMs have been associated with the capacity of glioma cells to effectively invade the brain and proliferate. Moreover, TMs are also used by some tumor cells to interconnect to one large, resistant multicellular network. Here, we performed a correlati...     »
Zeitschriftentitel:
J Neurosci
Jahr:
2017
Band / Volume:
37
Heft / Issue:
29
Seitenangaben Beitrag:
6837-6850
Sprache:
eng
Volltext / DOI:
doi:10.1523/JNEUROSCI.3532-16.2017
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28607172
Print-ISSN:
0270-6474
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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