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Title:

Effects of quercetin and catechin on hepatic glutathione-S transferase (GST), NAD(P)H quinone oxidoreductase 1 (NQO1), and antioxidant enzyme activity levels in rats

Document type:
Zeitschriftenaufsatz
Author(s):
Wiegand, Heike; Boesch-Saadatmandi, Christine; Regos, Ionela; Treutter, Dieter; Wolffram, Siegfried; Rimbach, Gerald
Abstract:
Cell culture data indicate that quercetin and catechin may affect the activity of phase II and antioxidant enzymes. However, little is known about the impact of dietary flavonoids in vivo. Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes glutathione-S transferase (GST) and NAD(P)H quinone oxidoreductase-1 (NQO1) in rat liver. Furthermore, the activity of the hepatic antioxidant enzymes c...     »
Keywords:
Animals; Catalase/genetics/metabolism; Catechin/administration {&} dosage/blood; Diet; Gene Expression Regulation, Enzymologic; Glutamate-Cysteine Ligase/genetics/metabolism; Glutathione Peroxidase/genetics/metabolism; Glutathione Transferase/genetics/metabolism; Glutathione/metabolism; Lipid Peroxidation; Liver/enzymology/metabolism; Male; NAD(P)H Dehydrogenase (Quinone)/genetics/metabolism; Protein Subunits/genetics/metabolism; Quercetin/administration {&} dosage/blood; Random Allocation; Rats...     »
Journal title:
Nutrition and cancer
Year:
2009
Journal volume:
61
Journal issue:
5
Pages contribution:
717--722
Fulltext / DOI:
doi:10.1080/01635580902825621
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