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Titel:

Early and late outcomes after surgical repair of congenital supravalvular aortic stenosis: a European Congenital Heart Surgeons Association multicentric study.

Dokumenttyp:
Journal Article; Article; Proceedings Paper
Autor(en):
Padalino, Massimo A; Frigo, Anna Chiara; Comisso, Marina; Kostolny, Martin; Omeje, Ikenna; Schreiber, Christian; Pabst von Ohain, Jelena; Cleuziou, Julie; Barron, David J; Meyns, Bart; Hraska, Viktor; Maruszewski, Bohdan; Kozlowski, Michal; Vricella, Luca A; Hibino, Narutoshi; Collica, Sarah; Berggren, Håkan; Synnergren, Mats; Lazarov, Stojan; Kalfa, David; Bacha, Emile; Pizarro, Christian; Hazekamp, Mark; Sojak, Vlado; Jacobs, Jeffrey P; Nosal, Matej; Fragata, Jose; Cicek, Sertac; Sarris, Georg...     »
Abstract:
Our goal was to evaluate the early and late results of the surgical management of congenital supravalvular aortic stenosis (SVAS).We performed a retrospective, multicentre study using data from the European Congenital Heart Surgeons Association. Exclusion criteria were age >18 years, operation before 1990 and redo supravalvular aortic stenosis operations. Multivariate Cox regression analysis was performed to detect independent predictors of adverse events.Of a total of 301 patients (male/female = 194/107; median age 3.9 years, range 13 days-17.9 years), 17.6% had a prior surgical or interventional procedure. Pulmonary artery stenosis was present in 41.5% and coronary anomalies in 13.6%. The operation consisted of a single patch repair in 36.7%, a pantaloon-shaped patch in 36.7%, a 3-patch technique in 14.3% and other techniques in 11.7%. Postoperative complications occurred in 14.9%, and the early mortality rate was 5%. At a median follow-up of 13 years (interquartile range 3.5-7.8; follow-up completed 79.1%), there were 10 late deaths (4.2%). A surgical reoperation or an interventional cardiology procedure occurred in 12.6% and 7.2%, respectively. No significant differences in outcomes between the techniques were found. Age at repair <12 months and pulmonary artery stenosis were associated with an increased risk of early (P = 0.0001) and overall mortality (P = 0.025), respectively. Having an operation after 2005 and co-existing pulmonary artery stenosis were significant predictors of late reintervention (P = 0.0110 and P = 0.001, respectively).Surgical repair of congenital stenosis is an effective procedure with acceptable surgical risk and good late survival, but late morbidity is not negligible, especially in infants and when associated pulmonary artery stenosis is present.
Zeitschriftentitel:
Eur J Cardiothorac Surg
Jahr:
2017
Band / Volume:
52
Heft / Issue:
4
Seitenangaben Beitrag:
789-797
Sprache:
eng
Volltext / DOI:
doi:10.1093/ejcts/ezx245
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29156017
Print-ISSN:
1010-7940
TUM Einrichtung:
Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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