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Title:

Mitochondrial adaptation in steatotic mice.

Document type:
Journal Article
Author(s):
Einer, Claudia; Hohenester, Simon; Wimmer, Ralf; Wottke, Lena; Artmann, Renate; Schulz, Sabine; Gosmann, Christian; Simmons, Alisha; Leitzinger, Christin; Eberhagen, Carola; Borchard, Sabine; Schmitt, Sabine; Hauck, Stefanie M; von Toerne, Christine; Jastroch, Martin; Walheim, Ellen; Rust, Christian; Gerbes, Alexander L; Popper, Bastian; Mayr, Doris; Schnurr, Max; Vollmar, Angelika M; Denk, Gerald; Zischka, Hans
Abstract:
Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically and biophysically analyzed mitochondria from steatotic wild type and immune-compromised mice fed a Western diet (WD) - enriched in saturated fatty acids (SFAs). WD-mitochondria demonstrated lipidomic changes, a decreased mitochondrial ATP production capacity and a sign...     »
Journal title abbreviation:
Mitochondrion
Year:
2018
Journal volume:
40
Pages contribution:
1-12
Language:
eng
Fulltext / DOI:
doi:10.1016/j.mito.2017.08.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28935446
Print-ISSN:
1567-7249
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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