@article{journal article,
	author = {Einer, Claudia and Hohenester, Simon and Wimmer, Ralf and Wottke, Lena and Artmann, Renate and Schulz, Sabine and Gosmann, Christian and Simmons, Alisha and Leitzinger, Christin and Eberhagen, Carola and Borchard, Sabine and Schmitt, Sabine and Hauck, Stefanie M and von Toerne, Christine and Jastroch, Martin and Walheim, Ellen and Rust, Christian and Gerbes, Alexander L and Popper, Bastian and Mayr, Doris and Schnurr, Max and Vollmar, Angelika M and Denk, Gerald and Zischka, Hans},
	title = {Mitochondrial adaptation in steatotic mice.},

	year = {2018},

        volume = {40},



        pages = {1-12},

        issn = {1567-7249},

        doi = {10.1016/j.mito.2017.08.015},

        language = {eng},

        abstract = {Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically and biophysically analyzed mitochondria from steatotic wild type and immune-compromised mice fed a Western diet (WD) - enriched in saturated fatty acids (SFAs). WD-mitochondria demonstrated lipidomic changes, a decreased mitochondrial ATP production capacity and a significant sensitivity to calcium. These changes preceded hepatocyte damage and were not associated with enhanced ROS production. Thus, WD-mitochondria do not promote steatohepatitis per se, but demonstrate bioenergetic deficits and increased sensitivity to stress signals.},


	
}