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Title:

Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death.

Document type:
Journal Article
Author(s):
Blecha, Jan; Novais, Silvia Magalhaes; Rohlenova, Katerina; Novotna, Eliska; Lettlova, Sandra; Schmitt, Sabine; Zischka, Hans; Neuzil, Jiri; Rohlena, Jakub
Abstract:
Mitochondrial electron transport chain (ETC) targeting shows a great promise in cancer therapy. It is particularly effective in tumors with high ETC activity where ETC-derived reactive oxygen species (ROS) are efficiently induced. Why modern ETC-targeted compounds are tolerated on the organismal level remains unclear. As most somatic cells are in non-proliferative state, the features associated with the ETC in quiescence could account for some of the specificity observed. Here we report that qui...     »
Journal title abbreviation:
Free Radic Biol Med
Year:
2017
Journal volume:
112
Pages contribution:
253-266
Language:
eng
Fulltext / DOI:
doi:10.1016/j.freeradbiomed.2017.07.033
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28774815
Print-ISSN:
0891-5849
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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