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Title:

SK2 channels regulate mitochondrial respiration and mitochondrial Ca uptake.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Honrath, Birgit; Matschke, Lina; Meyer, Tammo; Magerhans, Lena; Perocchi, Fabiana; Ganjam, Goutham K; Zischka, Hans; Krasel, Cornelius; Gerding, Albert; Bakker, Barbara M; Bünemann, Moritz; Strack, Stefan; Decher, Niels; Culmsee, Carsten; Dolga, Amalia M
Abstract:
Mitochondrial calcium ([Ca]) overload and changes in mitochondrial metabolism are key players in neuronal death. Small conductance calcium-activated potassium (SK) channels provide protection in different paradigms of neuronal cell death. Recently, SK channels were identified at the inner mitochondrial membrane, however, their particular role in the observed neuroprotection remains unclear. Here, we show a potential neuroprotective mechanism that involves attenuation of [Ca] uptake upon SK chann...     »
Journal title abbreviation:
Cell Death Differ
Year:
2017
Journal volume:
24
Journal issue:
5
Pages contribution:
761-773
Language:
eng
Fulltext / DOI:
doi:10.1038/cdd.2017.2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28282037
Print-ISSN:
1350-9047
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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