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Titel:

Five endometrial cancer risk loci identified through genome-wide association analysis.

Dokumenttyp:
Journal Article; Article
Autor(en):
Cheng, Timothy H T; Thompson, Deborah J; O'Mara, Tracy A; Painter, Jodie N; Glubb, Dylan M; Flach, Susanne; Lewis, Annabelle; French, Juliet D; Freeman-Mills, Luke; Church, David; Gorman, Maggie; Martin, Lynn; Hodgson, Shirley; Webb, Penelope M; Attia, John; Holliday, Elizabeth G; McEvoy, Mark; Scott, Rodney J; Henders, Anjali K; Martin, Nicholas G; Montgomery, Grant W; Nyholt, Dale R; Ahmed, Shahana; Healey, Catherine S; Shah, Mitul; Dennis, Joe; Fasching, Peter A; Beckmann, Matthias W; Hein, A...     »
Abstract:
We conducted a meta-analysis of three endometrial cancer genome-wide association studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and 37,144 controls of European ancestry. Genome-wide imputation and meta-analysis identified five new risk loci of genome-wide significance at likely regulatory regions on chromosomes 13q22.1 (rs11841589, near KLF5), 6q22.31 (rs13328298, in LOC643623 and near HEY2 and NCOA7), 8q24.21 (rs4733613, telomeric to MYC), 15q15.1 (rs937213, in...     »
Zeitschriftentitel:
Nat Genet
Jahr:
2016
Band / Volume:
48
Heft / Issue:
6
Seitenangaben Beitrag:
667-74
Sprache:
eng
Volltext / DOI:
doi:10.1038/ng.3562
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27135401
Print-ISSN:
1061-4036
TUM Einrichtung:
Frauenklinik und Poliklinik
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