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Title:

Methanobactin reverses acute liver failure in a rat model of Wilson disease.

Document type:
Journal Article
Author(s):
Lichtmannegger, Josef; Leitzinger, Christin; Wimmer, Ralf; Schmitt, Sabine; Schulz, Sabine; Kabiri, Yaschar; Eberhagen, Carola; Rieder, Tamara; Janik, Dirk; Neff, Frauke; Straub, Beate K; Schirmacher, Peter; DiSpirito, Alan A; Bandow, Nathan; Baral, Bipin S; Flatley, Andrew; Kremmer, Elisabeth; Denk, Gerald; Reiter, Florian P; Hohenester, Simon; Eckardt-Schupp, Friedericke; Dencher, Norbert A; Adamski, Jerzy; Sauer, Vanessa; Niemietz, Christoph; Schmidt, Hartmut H J; Merle, Uta; Gotthardt, Danie...     »
Abstract:
In Wilson disease (WD), functional loss of ATPase copper-transporting ? (ATP7B) impairs biliary copper excretion, leading to excessive copper accumulation in the liver and fulminant hepatitis. Current US Food and Drug Administration- and European Medicines Agency-approved pharmacological treatments usually fail to restore copper homeostasis in patients with WD who have progressed to acute liver failure, leaving liver transplantation as the only viable treatment option. Here, we investigated the...     »
Journal title abbreviation:
J Clin Invest
Year:
2016
Journal volume:
126
Journal issue:
7
Pages contribution:
2721-35
Language:
eng
Fulltext / DOI:
doi:10.1172/JCI85226
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27322060
Print-ISSN:
0021-9738
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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