User: Guest  Login
Title:

Lapatinib Resistance in Breast Cancer Cells Is Accompanied by Phosphorylation-Mediated Reprogramming of Glycolysis

Document type:
Zeitschriftenaufsatz
Author(s):
Ruprecht, Benjamin; Zaal, Esther A.; Zecha, Jana; Wu, Wei; Berkers, Celia R.; Kuster, Bernhard; Lemeer, Simone
Abstract:
HER2/ERBB2–overexpressing breast cancers targeted effectively by the small-molecule kinase inhibitor lapatinib frequently acquire resistance to this drug. In this study, we employed explorative mass spectrometry to profile proteome, kinome, and phosphoproteome changes in an established model of lapatinib resistance to systematically investigate initial inhibitor response and subsequent reprogramming in resistance. The resulting dataset, which collectively contains quantitative data for >7,800 pr...     »
Journal title:
Cancer Research
Year:
2017
Journal volume:
77
Journal issue:
8
Pages contribution:
1842-1853
Fulltext / DOI:
doi:10.1158/0008-5472.can-16-2976
Publisher:
American Association for Cancer Research (AACR)
E-ISSN:
0008-54721538-7445
Date of publication:
16.02.2017
 BibTeX