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Titel:

Lapatinib Resistance in Breast Cancer Cells Is Accompanied by Phosphorylation-Mediated Reprogramming of Glycolysis

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Ruprecht, Benjamin; Zaal, Esther A.; Zecha, Jana; Wu, Wei; Berkers, Celia R.; Kuster, Bernhard; Lemeer, Simone
Abstract:
HER2/ERBB2–overexpressing breast cancers targeted effectively by the small-molecule kinase inhibitor lapatinib frequently acquire resistance to this drug. In this study, we employed explorative mass spectrometry to profile proteome, kinome, and phosphoproteome changes in an established model of lapatinib resistance to systematically investigate initial inhibitor response and subsequent reprogramming in resistance. The resulting dataset, which collectively contains quantitative data for >7,800 pr...     »
Zeitschriftentitel:
Cancer Research
Jahr:
2017
Band / Volume:
77
Heft / Issue:
8
Seitenangaben Beitrag:
1842-1853
Volltext / DOI:
doi:10.1158/0008-5472.can-16-2976
Verlag / Institution:
American Association for Cancer Research (AACR)
E-ISSN:
0008-54721538-7445
Publikationsdatum:
16.02.2017
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