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Titel:

Targeting Elastase for Molecular Imaging of Early Atherosclerotic Lesions.

Dokumenttyp:
Journal Article; Article
Autor(en):
Glinzer, Almut; Ma, Xiaopeng; Prakash, Jaya; Kimm, Melanie A; Lohöfer, Fabian; Kosanke, Katja; Pelisek, Jaroslav; Thon, Moritz P; Vorlova, Sandra; Heinze, Katrin G; Eckstein, Hans-Henning; Gee, Michael W; Ntziachristos, Vasilis; Zernecke, Alma; Wildgruber, Moritz
Abstract:
Neutrophils accumulate in early atherosclerotic lesions and promote lesion growth. In this study, we evaluated an elastase-specific near-infrared imaging agent for molecular imaging using hybrid fluorescence molecular tomography/x-ray computed tomography.Murine neutrophils were isolated from bone marrow and incubated with the neutrophil-targeted near-infrared imaging agent Neutrophil Elastase 680 FAST for proof of principle experiments, verifying that the elastase-targeted fluorescent agent is s...     »
Zeitschriftentitel:
Arterioscler Thromb Vasc Biol
Jahr:
2017
Band / Volume:
37
Heft / Issue:
3
Seitenangaben Beitrag:
525-533
Sprache:
eng
Volltext / DOI:
doi:10.1161/ATVBAHA.116.308726
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28062502
Print-ISSN:
1079-5642
TUM Einrichtung:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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