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Title:

Cytochrome P450s in human immune cells regulate IL-22 and c-Kit via an AHR feedback loop.

Document type:
Journal Article; Article
Author(s):
Effner, Renate; Hiller, Julia; Eyerich, Stefanie; Traidl-Hoffmann, Claudia; Brockow, Knut; Triggiani, Massimo; Behrendt, Heidrun; Schmidt-Weber, Carsten B; Buters, Jeroen T M
Abstract:
The mechanisms how environmental compounds influence the human immune system are unknown. The environmentally sensitive transcription factor aryl hydrocarbon receptor (AHR) has immune-modulating functions and responds to small molecules. Cytochrome P4501 enzymes (CYP1) act downstream of the AHR and metabolize small molecules. However, it is currently unknown whether CYP1 activity is relevant for immune modulation. We studied the interdependence of CYP1 and AHR in human primary immune cells using...     »
Journal title abbreviation:
Sci Rep
Year:
2017
Journal volume:
7
Pages contribution:
44005
Language:
eng
Fulltext / DOI:
doi:10.1038/srep44005
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28276465
Print-ISSN:
2045-2322
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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