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Titel:

L-Arginine in the treatment of valproate overdose - five clinical cases.

Dokumenttyp:
Case Reports; Journal Article; Observational Study
Autor(en):
Schrettl, Verena; Felgenhauer, Norbert; Rabe, Christian; Fernando, Malkanthi; Eyer, Florian
Abstract:
Valproic acid and its metabolites - particularly valproyl-CoA - are inhibitors of the enzyme N-acetylglutamate synthetase. The amino acid l-arginine can stimulate N-acetylglutamate synthetase activity and could be potentially used therapeutically to correct hyperammonemia caused by valproate therapy or overdose. Severely valproic-acid-poisoned patients are usually treated with l-carnitine or hemodialysis in order to decrease hyperammonemia. We herein report of five cases, in which l-arginine was...     »
Zeitschriftentitel:
Clin Toxicol (Phila)
Jahr:
2017
Band / Volume:
55
Heft / Issue:
4
Seitenangaben Beitrag:
260-266
Sprache:
eng
Volltext / DOI:
doi:10.1080/15563650.2017.1284333
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28152637
Print-ISSN:
1556-3650
TUM Einrichtung:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker)
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