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Titel:

Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference With CD44v6 Signaling.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Matzke-Ogi, Alexandra; Jannasch, Katharina; Shatirishvili, Marine; Fuchs, Beatrix; Chiblak, Sara; Morton, Jennifer; Tawk, Bouchra; Lindner, Thomas; Sansom, Owen; Alves, Frauke; Warth, Arne; Schwager, Christian; Mier, Walter; Kleeff, Jörg; Ponta, Helmut; Abdollahi, Amir; Orian-Rousseau, Véronique
Abstract:
Cancer cells with high metastatic potential and stem cell-like characteristics express the cell surface marker CD44. CD44 isoforms that include the v6 exon are co-receptors for the receptor tyrosine kinases MET and Vascular Endothelial Growth factor Receptor-2 (VEGFR-2). We studied CD44v6 signaling in several pancreatic cancer cell lines, and its role in tumor growth and metastasis in several models of pancreatic cancer.We analyzed the effects of v6 peptides that interfere with the co-receptor f...     »
Zeitschriftentitel:
Gastroenterology
Jahr:
2016
Band / Volume:
150
Heft / Issue:
2
Seitenangaben Beitrag:
513-25.e10
Sprache:
eng
Volltext / DOI:
doi:10.1053/j.gastro.2015.10.020
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26597578
Print-ISSN:
0016-5085
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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