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Title:

Minimally manipulated murine regulatory T cells purified by reversible Fab Multimers are potent suppressors for adoptive T-cell therapy.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Mohr, Fabian; Fischer, Julius Clemens; Nikolaus, Marc; Stemberger, Christian; Dreher, Stefan; Verschoor, Admar; Haas, Tobias; Poeck, Hendrik; Busch, Dirk H
Abstract:
The transfer of regulatory T cells, either freshly isolated, or modified, represents a promising therapeutic approach to dampen misdirected immune responses, like autoimmune diseases, chronic inflammatory syndromes and graft versus host disease. Clinical isolation of highly pure regulatory T cell (Treg) populations is still challenging and labeling reagents can influence their viability and functionality, potentially altering the potency of isolated Treg cell products. Here we show that reversib...     »
Journal title abbreviation:
Eur J Immunol
Year:
2017
Journal volume:
47
Journal issue:
12
Pages contribution:
2153-2162
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.201747137
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28833039
Print-ISSN:
0014-2980
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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