Benutzer: Gast  Login
Titel:

High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4 T cells in both mice and humans.

Dokumenttyp:
Journal Article
Autor(en):
Manfrini, Nicola; Ricciardi, Sara; Miluzio, Annarita; Fedeli, Maya; Scagliola, Alessandra; Gallo, Simone; Brina, Daniela; Adler, Thure; Busch, Dirk H; Gailus-Durner, Valerie; Fuchs, Helmut; Hrab? de Angelis, Martin; Biffo, Stefano
Abstract:
Eukaryotic Initiation Factor 6 (eIF6) is required for 60S ribosomal subunit biogenesis and efficient initiation of translation. Intriguingly, in both mice and humans, endogenous levels of eIF6 are detrimental as they act as tumor and obesity facilitators, raising the question on the evolutionary pressure that maintains high eIF6 levels. Here we show that, in mice and humans, high levels of eIF6 are required for proper immune functions. First, eIF6 heterozygous (het) mice show an increased mortal...     »
Zeitschriftentitel:
Dev Comp Immunol
Jahr:
2017
Band / Volume:
77
Seitenangaben Beitrag:
69-76
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.dci.2017.07.022
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28743432
Print-ISSN:
0145-305X
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX