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Title:

Prevalence of sexual dimorphism in mammalian phenotypic traits.

Document type:
journal article
Author(s):
Karp, Natasha A; Mason, Jeremy; Beaudet, Arthur L; Benjamini, Yoav; Bower, Lynette; Braun, Robert E; Brown, Steve D M; Chesler, Elissa J; Dickinson, Mary E; Flenniken, Ann M; Fuchs, Helmut; Angelis, Martin Hrabe de; Gao, Xiang; Guo, Shiying; Greenaway, Simon; Heller, Ruth; Herault, Yann; Justice, Monica J; Kurbatova, Natalja; Lelliott, Christopher J; Lloyd, K C Kent; Mallon, Ann-Marie; Mank, Judith E; Masuya, Hiroshi; McKerlie, Colin; Meehan, Terrence F; Mott, Richard F; Murray, Stephen A; Parki...     »
Abstract:
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
Journal title abbreviation:
Nat Commun
Year:
2017
Journal volume:
8
Pages contribution:
15475
Language:
eng
Fulltext / DOI:
doi:10.1038/ncomms15475
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28650954
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Molekulare Allergologie
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